Senior Scientist II, DNA Technology

About Generate Biomedicines

Generate Biomedicines is a new kind of therapeutics company – existing at the intersection of machine learning, biological engineering, and medicine – pioneering Generative Biology™ to create breakthrough medicines where novel therapeutics are computationally generated, instead of being discovered. Generate has built a machine learning-powered biomedicines platform with the potential to generate new drugs across a wide range of biologic modalities. This platform represents a potentially fundamental shift in what is possible in the field of biotherapeutic development.

We pursue this audacious vision because we believe in the unique and revolutionary power of generative biology to radically transform the lives of billions, with an outsized opportunity for patients in need. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!

Generate was founded in 2018 by Flagship Pioneering and has received over $420 million in funding, providing the resources to rapidly scale the organization. The Company has offices in Somerville and Andover, Massachusetts with over 275 employees.

The Role:

We are seeking a highly motivated and detail-oriented Senior Scientist II, DNA Technology to join our team, with a primary focus on developing and scaling high-throughput DNA assembly processes to support large-scale data generation at Generate. The ideal candidate will possess deep technical expertise in nucleic acid manipulation, hands-on experience with NGS technologies, and strong bioinformatics and coding capabilities.

This individual will play a pivotal role in advancing our synthetic biology platforms by collaborating extensively across teams -- including HTP Protein Production, Protein Engineering, Quantitative Biology, and Prototyping Labs teams – to support broader discovery pipelines. The successful candidate will bring a passion for innovation, strong scientific rigor, a collaborative spirit, and a startup mindset.

Here's how you will contribute:

• Design, implement and scale high-throughput, automation-compatible DNA assembly, cloning and QC workflows for downstream screening and optimization efforts.
• Integrate DNA production pipelines with various protein expression and display platforms, ensuring seamless handoffs and compatibility across systems.
• Collaborate cross-functionally with NGS, bioinformatics, protein science, and automation teams to drive experimental design, data analysis, and platform integration.
• Provide scientific and technical expertise on other synthetic biology workflows, including design and construction of complex DNA libraries (e.g., megasets).
• Mentor and support junior team members and ensure scientific rigor in experimental planning and execution.
• Maintain detailed documentation of experimental protocols, results and interpretations in electronic lab notebooks (ELNs).

The Ideal Candidate will have:

• PhD. in Molecular Biology, Synthetic Biology, Bioengineering, or related discipline with 6+ years of relevant postdoctoral or industry experience.
• Demonstrated expertise in multi-part DNA assembly techniques (Golden Gate, Gibson Assembly, in vivo recombination) using synthetic DNA fragments or oligo pools.
• Experience designing and executing pooled, high-throughput screens and assays (e.g., pooled RNAi/CRISPR screen, displayed antibody selections, etc.)
• Proficiency in generating and interpreting NGS data (Illumina, nanopore, PacBio) in the context of pooled assays.
• Strong analytical skills and a meticulous approach to data quality, experimental troubleshooting, and process improvement.
• Excellent collaboration and communication skills with a team-oriented mindset and the ability to manage multiple priorities in a dynamic environment.

Nice to have:

• Hands-on experience with display technologies (e.g., phage, yeast, bacterial, ribosomal, or mammalian).
• Proficiency in Python/R for NGS data analysis and automation.
• Experience with microfluidics for ultrahigh-throughput applications.
• Familiarity with lab automation platforms.

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This role offers a unique opportunity to shape the future of high-throughput synthetic biology workflows at Generate. If you are passionate about molecular innovation and thrive in a collaborative, fast-paced environment, we encourage you to apply.

Generate Biomedicines iscommitted to equal employment opportunityregardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

COVID Safety:

Generate Biomedicines enforces a mandatory vaccination policy for COVID-19. All employees must be fully vaccinated and have received a booster. The purpose of this policy is to safeguard the health of our employees, their families, and the community at large from infectious disease that may be reduced by vaccinations. The company will make exceptions to this policy if required by applicable law and will consider requests for an exemption from this policy due to a medical reason, or because of a sincerely held religious belief, or any other exemptions that may be recognized by applicable.

Recruitment & Staffing Agencies: Generate Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate Biomedicines or its employees is strictly prohibited unless contacted directly by Generate Biomedicines’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate Biomedicines, and Generate will not owe any referral or other fees with respect thereto.

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